Navigator for the sleep cluster — how much sleep to aim for, whether each arm of the
mortality/metabolic U-curve is a real causal signal or an artifact of illness, whether regularity of
timing is a distinct lever, and what to do about insomnia. Nucleus: Sleep Duration and Mortality.
How much sleep, and is the U-curve real?
- Sleep Duration and Mortality — whether the short/long mortality U-curve is causal or a marker of illness, and why the two arms are not the same kind of finding
- Sleep and Metabolic Health — whether sleep duration causally affects type 2 diabetes risk and adiposity, and which arm of the U-curve is real
- Sleep and Cognitive Decline — whether sleep disorders raise dementia / cognitive-decline risk, which disorders on which outcomes, and whether the long-sleep arm is causal or a preclinical marker
Beyond duration — regularity and treatment
- Sleep Regularity and Mortality — whether day-to-day consistency of sleep timing (Sleep Regularity Index) is a distinct and stronger mortality lever than hours slept
- Sleep Aids and Insomnia Treatment — for chronic insomnia, which works and is safest among CBT-I, prescription hypnotics, and melatonin
- Sleep Apnea Treatment and Cardiovascular Risk — whether treating obstructive/central sleep apnea with CPAP reduces hard cardiovascular events and death, or only the daytime symptoms